F. Murray Abraham as BERT DI GRASSO – Visiting Sicily with his son, Dominic (Michael Imperioli), and grandson, Albie (Adam DiMarco), Bert is getting frail, yet still sees himself as virile and capable.

 

Jennifer Coolidge as TANYA MCQUOID-HUNT - A wealthy, unstable woman, traveling with her husband, Greg (Jon Gries), and assistant, Portia (Haley Lu Richardson). 

 

Adam DiMarco as ALBIE DI GRASSO – Dominic’s (Michael Imperioli) son and Bert’s  (F. Murray Abraham) grandson, Albie is a sweet and observant college grad, who often serves as his family’s peacekeeper.  

 

Meghann Fahy as DAPHNE SULLIVAN – A stay-at-home mom visiting Italy with her husband, Cameron (Theo James), and another couple, Ethan (Will Sharpe) and Harper (Aubrey Plaza).

 

Jon Gries as GREG - Tanya’s (Jennifer Coolidge) husband, who is less than pleased to find her assistant invited on their romantic getaway. 

 

Beatrice Grannò as MIA - A Sicilian local, Mia is a talented singer in search of her big break.

 

Tom Hollander as QUENTIN - an English expat, vacationing with his friends and his nephew, Jack (Leo Woodall).

 

Sabrina Impacciatore as VALENTINA - The passionate, dedicated manager in charge of the White Lotus resort in Taormina, who expects perfection from her staff. 

 

Michael Imperioli as DOMINIC DI GRASSO – A Hollywood producer visiting Sicily with his elderly father, Bert (F. Murray Abraham), and post-college son, Albie (Adam DiMarco), to explore their ancestral roots. 

 

Theo James as CAMERON SULLIVAN – A wildly successful businessman from a wealthy family, Cameron is vacationing with his wife Daphne (Meghann Fahy), his college roommate, Ethan (Will Sharpe), and Ethan’s wife, Harper (Aubrey Plaza).

 

Aubrey Plaza as HARPER SPILLER – Newly wealthy after her husband finds professional success, Harper and Ethan (Will Sharpe) are visiting Italy with Ethan’s college roommate, Cameron (Theo James), and Cameron’s wife, Daphne (Meghann Fahy). 

 

Haley Lu Richardson as PORTIA – A small-town girl and recent college graduate, Portia is traveling with her boss, Tanya (Jennifer Coolidge), hoping for adventure.

 

Will Sharpe as ETHAN SPILLER – After recently striking professional success, Ethan and his wife, Harper (Aubrey Plaza), are invited to vacation in Italy with his college roommate, Cameron (Theo James), and Cameron’s wife, Daphne (Meghann Fahy). 

Simona Tabasco as LUCIA- a Sicilian local who frequents the White Lotus resort in search of work and opportunity amongst the wealthy clientele. 

 

Leo Woodall as JACK – a magnetic guest staying at The White Lotus with his uncle, Quentin (Tom Hollander).